By Christian Dani, Nathalie Billon (auth.), Michael E. Symonds (eds.)
This e-book is designed to supply a finished perception into present views and demanding situations in adipose tissue biology. In <i>Adipose Tissue Biology</i>, scientists and clinicians talk about adipocyte precursors, differentiation and development, brown and white adipose tissue, gender, irritation, nutritional and genetic determinants of fats mass, including evolutionary and developmental points of adiposity.
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Additional info for Adipose Tissue Biology
2009; Hernández-Morante et al. 2009). A number of adipocyte-specific factors show rhythmic expression. Some examples are leptin, adipsin, resistin, adiponectin and visfatin, all of them showing circadian rhythmicity, For example, adiponectin shows both ultradian pulsatility and a diurnal variation (Gómez-Abellan et al. 2010). Recently, nocturnin, a circadianregulated gene, has been demonstrated to promote adipogenesis by stimulating PPAR-g nuclear translocation and enhancing its transcriptional activity (Kawai et al.
It is difficult to draw a clear border between both tissue types by visual inspection in this classical brown adipose tissue depot. In other adipose tissue depots, the categorization is even more complicated. Some depots usually regarded as white adipose tissue contain some interspersed brown adipocytes, and vice versa, within classical brown adipose tissue depots, white adipocytes are found. Furthermore, the fraction these cells constitute is not stable and can be altered by the ambient temperature or during developmental processes.
J Biol Chem 275:16845–16850 Zhu Y, Qi C, Korenberg JR et al (1995) Structural organization of mouse peroxisome proliferatoractivated receptor gamma (mPPARgamma) gene: alternative promoter use and different splicing yield two mPPARgamma isoforms. Proc Natl Acad Sci USA 92:7921–7925 Chapter 3 Brown Adipose Tissue Martin Klingenspor and Tobias Fromme Abstract A constant body temperature can only be maintained when the rate of heat dissipation equals the rate of heat loss. Thermoregulatory heat production mechanisms compensating heat loss are classically categorized as shivering and non-shivering thermogenesis.