By James D. Goldberg, Mitchell S. Golbus (auth.), Harry Harris, Kurt Hirschhorn (eds.)
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Additional resources for Advances in Human Genetics 1
1986) a See footnote to Table I. which provides adequate material for five or six restriction enzyme digestions. DNA Disorders Diagnosed The disorders that have been attempted or diagnosed by CVS in the first trimester are listed in Table IX. As mentioned above, this list is rapidly expanding. Pitfalls in DNA Diagnosis of Chorionic Villi Prenatal diagnoses using chorionic villi and recombinant DNA technology have the same pitfalls as any type of prenatal molecular analysis. These include: (1) maternal contamination of the DNA, (2) probe contamination, (3) technical difficulties, such as incomplete restriction digestion, (4) meiotic crossover when linkage analysis is being used, and (5) nonpaternity.
1986, First trimester prenatal diagnosis of cystic fIbrosis with linked DNA probes, Lancet 2:1402-1405. Ferguson-Smith, M. , and Yates, J. R. , 1984, Maternal age specifIc rates for chromosome aberrations and factors influencing them. Report of a collaborative study on 52,965 amniocenteses, Prenat. Diagn. 4:5-44. Chapter 1: Chorionic Villus Sampling 21 Ford, J. , and Jahnke, A. , 1983, Handling chorionic villi for direct chromosome studies, Lancet 2:1491-1492. Gibbs, D. , McFadyen, 1. , Crawfurd, M.
And Coleman, D. , 1983, Assessment of a transcervical aspiration technique for chorionic villus biopsy in the fIrst trimester of pregnancy, Br. J. Obstet. Gynaecol. 90:196-198. Jackson, L. ), 1985, CVS Latest News (Jefferson Medical College, Philadelphia), 1985(February 5). Jackson, L. ), 1986, CVS Latest News (Jefferson Medical College, Philadelphia), 1986(September 12). , Sigler, M. , and Schulman, J. , 1986, Non-viable pregnancy in patients anticipating chorionic villus sampling, Am. J. Hum.