Aplastic Anemia: Pathophysiology and Approaches to Therapy - download pdf or read online

By H. Heimpel (auth.), Hermann Heimpel M. D., Edward C. Gordon-Smith M. D., Wolfgang Heit M. D., Bernhard Kubanek M. D. (eds.)

Research on aplastic anaemia has till lately been constrained to medical description, morphology and epidemiology. New tips on how to tradition haemopoietic cells, and advances in our wisdom of proliferation and differentiation within the haemopoietic telephone method .opened a brand new zone of medical curiosity for this "prototype" of haemopoietic failure. moreover, bone marrow transplantation turned not just a medical approach to therapy, but additionally a resource of knowledge valuable for the dialogue of pathophysiological versions of aplastic anaemia. this example brought on us to rearrange a world con­ ference on aplastic anaemia, with specific emphasis on its patho­ body structure and the rationals of the present healing techniques. This convention used to be held at Schloss Reisensburg from July 20-22, 1978 with the participation of either experimental and scientific scientists energetic during this box or in comparable components of analysis. The complaints of the symposion mirror the current wisdom in addition to the numerous new questions which arose from the discussions. The editors are gratefully indebted to the individuals of this assembly, to Gerlinde Trogele and the entire co-workers of the Uni­ versity of Ulm engaged in coaching of this symposium and of this quantity, and final now not least to all sponsors who supplied the monetary foundation for this medical event.

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2] did not find any causal association between organic solvents x_. -______ o 10 20 30 40 50 60 >70 AGE Fig. 1. Different age composition of Korean (x x) and Swedish (0---0) materials of aplastic anemia. The figures in both materials represent total number of patients during the time of investigation, not annual frequencies Epidemiology and Aetiology of Aplastic Anemia 29 and aplastic anemia in Japan. But, on the other hand, they list results from other Japanese studies in which organic solvents were suspected as causative factors in 6-12 per cent of patients with aplastic anemia.

Of patients Chloramphenicol Insecticides Benzol Chloramphenicol and insecticides Atabrine Ephedrine Terramycin Salvarsan, quinine, chloroquine and hair dye - one patient each 30 29 7 4 2 2 2 Table 3. Drugs and chemicals associated with aplastic anemia in 81 patients [from Whang, 14] 4 4. Differences in drug use. Another explanation for the difference between East and West seems to be that drug use is different. , evidently is used extensively in the far East. The study by Yoshimatsu et al. [15] is especially elucidating.

Strauss, R. , Bove, K. : Acquired immunodeficiency in hepatitis associated aplastic anemia. J. Pediatr. 86,910-912 (1975) 36. : Studies on hemopoietic microenvironments. Exp. Hemat. 3, 213-226 (1975) 37. : Bone Marrow Stroma in Aplastic Anemia. In: Aplastic Anemia. ). Tokyo: Univ. Tokyo, 1978, pp. 109-121 38. , Haak, H. : Aplastic anemia: Histological investigation of methacrylate embedded bone marrow biopsy specimens; correlation with survival after conventional treatment in 15 adult patients.

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