By Eric Hollander
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Extra resources for Autism Spectrum Disorders (Medical Psychiatry Series)
A research note. J Child Psychol Psychiatry 1997; 38(2):247–251. Towbin KE. Pervasive developmental disorder not otherwise speciﬁed. In: Cohen DJ, Volkmar FR, eds. Handbook of Autism and Pervasive Developmental Disorders. 2nd ed. New York: Wiley, 1997:123–147. Lord C. Diagnostic instruments in autism spectrum disorders. In: Cohen DJ, Volkmar FR, eds. Handbook of Autism and Pervasive Developmental Disorders. 2nd ed. New York: Wiley, 1997:460–483. Le Couteur A, Rutter M, Lord C, Rios P. Autism Diagnostic Interview: a standardized investigator-based instrument.
This could be directly due to effects of 5-HT on social functioning, or indirectly in that patients less impaired by severe compulsivity, craving for sameness, and rigid adherence to routines may have greater opportunities for improving social functioning. , impulsivity/aggression, affective instability). Thus, genetic, neurobiological, and treatment studies must also address these comorbid conditions and associated features to have a more robust impact on understanding and treating autistic patients.
The effects of these drugs on different core dimensions were evident. Fluvoxamine targeted all three dimensions, causing improvements in repetitive thoughts/behaviors, social relatedness, and language usage, while risperidone targeted repetitive behaviors/restricted interests with no measurable change in social behavior and language. Nevertheless, it is still necessary to determine whether each dimension has distinct neurobiological/genetic mechanisms and differential treatment response. Other associated problem behaviors occur within the autistic syndrome (attentional difﬁculties, self-injurious behavior, mental retardation, self-stimulation, affective instability, EEG abnormalities), but the three core symptom domains appear to be necessary and minimum dimensional components of the syndrome.