Autoimmune Disease: Pathogenesis, Genetics, Immunotherapy, by Duncan Dartrey Adams PDF

By Duncan Dartrey Adams

This e-book describes how the Jerne-Burnet Forbidden Clone thought and the Adams-Knight H Gene concept, solved the pathogenesis and genetics of the autoimmune illnesses displaying how particular immunotherapy and prophylaxis should be built. additionally, Ebringer's discovery of 2 microbial triggers of autoimmune ailments is defined and the belief drawn that each one autoimmune ailments have microbial triggers, so should be preventable by way of the discovering of the triggers and vaccination opposed to them.

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Additional resources for Autoimmune Disease: Pathogenesis, Genetics, Immunotherapy, Prophylaxis and Principles for Organ Transplantation

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Autoimmune. ) [22, 24] Schizophrenia 39 The Knight Model of Schizophrenia Working on Graves’ disease, John Knight (Fig. 1) realized that schizophrenia has many similar aetiological features [25, 26]. Accordingly, he postulated that forbidden clones of B lymphocytes develop by somatic mutation, and make autoantibodies that act on neuronal cell receptors to affect the function of the brain’s limbic system. Knight proposed that: The familial aggregation is due to H genes and V genes. The wait for V gene mutation explains the 50 % discordance of monozygous twins and the juvenile grace gap (relative absence in children).

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New York: McGraw-Hill; 2001;1937–1946. 51. Fallon MD, Schwamm HA. Paget’s disease of bone. Pathology Annual 1989;24:Part 1:115–159 52. Williams DG, Peters DK. Glomerulonephritis and renal manifestations of systemic disease. In: Weatheral DJ, Ledingham JGG, Warrell DA, editors. Oxford textbook of medicine. 2nd ed. University Press: Oxford; 1987. p. 36–55. 53. Bisno AL. Rheumatic fever. In: Wyngaarden JB, Smith LM, editors. Textbook of Medicine. 17th ed. Saunders: Philadelphia; 1985. p. 1527–33. 54.

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