By Goutam Brahmachari
Bioactive traditional items are a wealthy resource of novel therapeutics. hence, the quest for bioactive molecules from nature maintains to play a tremendous position in fashioning new medicinal brokers. This quantity, which includes 16 chapters written through lively researchers and major specialists in ordinary items chemistry, brings jointly an summary of present discoveries during this striking box. It additionally offers info at the business program of traditional items for medicinal reasons. This ebook will function a invaluable source for researchers to foretell promising leads for constructing prescribed drugs to regard a variety of illnesses and sickness manifestations.
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Extra info for Bioactive Natural Products: Opportunities and Challenges in Medicinal Chemistry
2. Natural Products in Traditional Medicine: A Historical Perspective in Brief Natural products (including plants, animals and minerals) have been the basis of treatment of human diseases. History of medicine dates back practically to the existence of human civilization. Modern medicine system has gradually developed over the years by scientific and observational efforts of scientists; however, the basis of its development remains rooted in traditional medicine and therapies, prevailing throughout the world for thousands of years, which continue to provide mankind with new remedies.
248–251 It received final approval from the US Food and Drug Administration on March 2005 and gained approval in the European Union on April 25, 2008. The drug (21) inhibits the production of 1,3-β-D-glucan, an essential polysaccharide component of fungal cell wall; this decreased glucan production leads to osmotic instability and thus cellular lysis;248–260 since January 2008, micafungin has been approved for the prophylaxis of Candida infections in patients undergoing hematopoietic stem cell transplantation.
Are in clinical trials for drug development. e. qxd 9/7/2011 4:23 PM b1214 Page 13 Bioactive Natural Products Natural Products in Drug Discovery 13 presented on sources of new drugs from 1981 to 200751,72 indicate that almost half of the drugs approved since 1994 are based on natural products. 52 Between 2001 and 2005, 23 new drugs derived from natural products were introduced for the treatment of disorders such as bacterial and fungal infections, cancer, diabetes, dyslipidemia, atopic dermatitis, Alzheimer’s disease and genetic diseases such as tyrosinaemia and Gaucher disease; two drugs have been approved as immunosuppressive agents and one for pain management.