Download e-book for iPad: Bioelectronic Nose: Integration of Biotechnology and by Tai Hyun Park

By Tai Hyun Park

The “bioelectronic nose”, the equipment which has an analogous functionality to the human scent sensing approach, may be discovered through combining the olfactory cells or receptors with nanotechnology. within the final twenty years, a lot has been realized concerning the scent sensing mechanism in organic structures. With wisdom concerning the organic olfactory process and the thoughts for the expression of organic receptor proteins, we will make the most of organic fabrics and platforms to imitate the organic olfactory method. as well as the advances in organic and biotechnological zone, nanotechnology has stepped forward to a very good measure. The bioelectronic nostril is an efficient instance of the combination of biotechnology and nanotechnology.

The function of this ebook is to supply the reader with an idea, simple sciences, primary applied sciences, purposes, and views of the bioelectronic nostril.

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4 OSNs expressing dorsal receptors project to the dorsal portion of the OB, and the same logic applies to the ventral receptors. The projections from the OB to the accessory olfactory nucleus ( AON) also have the same pattern with the dorsal glomeruli projecting to the dorsal regions in the AON. On the other hand, the projections to the piriform seem to be organized randomly, and the projections to the amygdala are heavily biased towards the dorsal glomeruli olfactory nucleus, piriform cortex, lateral enterorhinal cortex, olfactory tubercle and the amygdala [99].

The organization of the glomeruli follows the logic of the epithelium where all the dorsal receptors project to the dorsal portion of the OB, while the class II ventral receptors project to the ventral portion of the bulb. The glomeruli in the OB are connected to one another by the dendro-dendritic connections of local inhibitory interneurons found in the glomerular layer [94–96]. It seems that these neurons are capable of silencing neighboring glomeruli responding with lower intensity to the same odor in order to reduce redundancy [97].

Cell 117(6):817–831 92. Yu CR et al (2004) Spontaneous neural activity is required for the establishment and maintenance of the olfactory sensory map. Neuron 42(4):553–566 93. Tadenev ALD et al (2011) Loss of Bardet-Biedl syndrome protein-8 (BBS8) perturbs olfactory function, protein localization, and axon targeting. Proc Natl Acad Sci 108(25):10320– 10325 94. : the heterogeneity of so-called periglomerular cells. Neurosci Res 30(2):101–110 95. Pinching AJ, Powell TPS (1971) The neuropil of the glomeruli of the olfactory bulb.

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