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The concept of this publication was once conceived within the context pointed out above with the target to aid in claiming a few of the difficulties for regulate researchers, beginning discussions and commencing interactive debates among the keep watch over and biology groups, and, eventually, to alert graduate scholars to the numerous attention-grabbing rules on the frontier among keep watch over suggestions conception and biology.
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Additional resources for Biology and control theory: current challenges
0 viral load assays: a Canadian evaluation. Journal of Clinical Virology, 11:189–202, 1998. 22. A. Berger et al. 0 assays for quantitation of HIV-1 RNA in plasma samples. Journal of Clinical Virology, 33:43–51, 2005. Modeling of the HIV/AIDS Infection 43 23. R. Galli, L. Merrick, M. Friesenhahn, and R. Ziermann. 5 assays on 1000 clinical specimens. Journal of Clinical Virology, 34:245–252, 2005. 24. K. Israel-Ballard et al. 0 (bDNA) assay quantiﬁcation of HIV-1 RNA viral load in breast milk. Journal of Clinical Virology, 34:253–256, 2005.
2 The Data Sampling Scheduling Remind that the measured data are the viral load and the total CD4 T-cells count. A. H. 5 0 0 20 40 60 80 100 time (day) Data Day of measurement 1 d0 2 d1 3 d2 4 d4 (or d6 ) 5 d12 (±2 days) 6 d19 (±2 days) 7 d30 (±2 days) 8 d45 (±2 days) 9 d60 (±2 days) 10 d75 (±2 days) 11 d90 (±2 days) Fig. 3. Planning of data measurements during the clinical trial. d0 is the ﬁrst day of the trial for the patient. di is equal to the day d0 + i. planning described in Figure 3. The day di is equal to the day d0 + i.
As a result, its dynamic can reveal high Modeling of the HIV/AIDS Infection 39 Table 4. Λmax shows a good immune system status for these patients. , and 11 samples. std is the standard deviation. ρ is the mean-based variability of the parameters estimates. 9%) Table 5. 48/mm3 < 200/mm3 ) predicts an immunological failure for patient 03. 38/mm3 200/mm3 . 8%) frequencies dynamics (non-predictive of the HIV infection) if the sample step is small enough. This result suggests that the sample step for the CD4 count should be larger in future trials.