Biology of Renal Cell Carcinoma - download pdf or read online

By Ronald M. Bukowski M.D., James H. Finke Ph.D., Eric A. Klein M.D. (auth.)

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M. Molecular and cellular characterization of human renal cell carcinoma cell lines. Cancer Res, 52: 348-356, 1992. 11. F. Cytogenetics of renal cell carcinomas associated with von Hippel- Lindau disease. Genes. Chromosom. Cancer, 3:256-262,1991. 12. , and Zbar, B. Specific genetic change in tumors associated with von Hippel-Lindau disease. JNatI Cancer Inst, 81: 1097-1101, 1989. 13. G. Genetics of human cancer. Ann Rev Genet, 20:231-251,1986. 14. I. Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma.

Previously, we demonstrated a low frequency ofloss of heterozygosity (LOR) on chromosome 17p (17 %) in sporadic RCC, suggesting that the p53 gene, which is located on chromosome 17p, is rarely involved in the tumorigenesis of RCC in spite of the wide prevalence of p53 alteration in other human cancers (32). To test whether MDM2 gene amplification could also be involved in the functional loss of the p53 protein in RCC tumorigenesis, we examined MD M2 gene alteration in sporadic RCCs by Southern blot analysis.

Cell 54: 593-595, 1988. 10. Derynek R, Geoddel DV, Ullrieh A, et al. Synthesis of messenger RNAs for transforming growth Yoshida et al. 31 factor ex and Pand the epidermal growth factor receptor by human tumors. Cancer Res 47: 707712, 1987. 11. Mydlo JH, Miehaeli J, Cordon-Cardo C, Goldenberg AS, Heston WDW, Fair WR. Expression of transfonning growth factor ex and epidermal growth factor receptor messenger RNA in neoplastic and nonneoplastic human kidney tissue. Cancer Res 49; 3407-3411, 1989. 12.

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