By Marja Makarow, Ineke Braakman
Molecular chaperones engage with almost each newly synthesized protein. This quantity assembles a set of experiences on molecular chaperones that's either well timed and easy. The publication uniquely combines the fundamentals of the topic quarter with the newest effects. This makes it a very good front for newbies into the sector and is appropriate for educating reasons. It additionally presents a resource of considerable info for specialists.
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Extra resources for Chaperones (Topics in Current Genetics)
Biol Reprod 70:18-24 Jakobsen BK, Pelham HR (1988) Constitutive binding of yeast heat shock factor to DNA in vivo. Mol Cell Biol 8:5040-5042 Jedlicka P, Mortin MA, Wu C (1997) Multiple functions of Drosophila heat shock transcription factor in vivo. EMBO J 16:2452-2462 Jolly C, Morimoto R, Robert-Nicoud M, Vourc’h C (1997) HSF1 transcription factor concentrates in nuclear foci during heat shock: relationship with transcription sites. J Cell Sci 110:2935-2941 Jolly C, Usson Y, Morimoto RI (1999) Rapid and reversible relocalization of heat shock factor 1 within seconds to nuclear stress granules.
1993; Cotto et al. 1997; Jolly et al. 1997; Holmberg et al. 2000; Denegri et al. 2002; for review see Biamonti 2004). The nSBs are structures distinct from other known subnuclear compartments such as PML bodies and Cajal bodies (Cotto et al. 1997). Although nSBs do not coincide with the sites of hsp70 and hsp90 transcription (Jolly et al. 1997), the observations that nSBs relocalize to the same sites upon repeated heat shocks and that the number of nSBs correlates with ploidy of the cell have indicated a physical association with chromosomal structures (Jolly et al.
Elegans with extended life span is associated with delayed aggregation and toxicity of polyQ expansions. Furthermore, inactivation of DAF-16, HSF1 or sHsps accelerated the aggregation of polyQ-containing proteins (Hsu et al. 2003). These findings suggest that the regulation of aging as well as the detection and prevention of misfolded and aggregation-prone proteins likely share common determinants, the characterization of which will be important in order to understand the molecular mechanisms underlying age-dependent health problems, such as neurodegenerative diseases.