Read e-book online Clinical Neuroembryology: Development and Developmental PDF

By Hans J. ten Donkelaar, Martin Lammens, Akira Hori

The striking growth in developmental neurobiology, the dramatic advances in (neuro)genetics and the excessive solution of the fashionable imaging ideas acceptable to developmental issues of the human mind and spinal twine have created a unique perception into the developmental background of the primary apprehensive approach (CNS). scientific Neuroembryology offers a entire evaluate of the advance of the human CNS within the context of its many developmental problems because of genetic, environmental and hypoxic reasons. it's exact within the mixture of information from human embryology, animal learn and developmental neuropathology.

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Additional info for Clinical Neuroembryology: Development and Developmental Disorders of the Human Central Nervous System

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1995; Kollias and Ball 1997; Barkovich 2000). Every disorder that influences the development of the commissural plate may lead to this malformation. Dysgenesis of the corpus callosum occurs in approximately 20% of cases as an isolated disorder, but in about 80% of cases in combination with other disorders of the brain (Chap. 10). 4 Imaging of the Fetal Brain Fetal magnetic resonance images at 20 and 35 weeks of development are shown in Figs. 27, respectively. At 20 weeks of development, cortical layers, the hypodense subplate in particular, can be easily distinguished in the smooth cerebral cortex.

8 Fetal Development of the Brain Fig. 24 Radial and tangential migration of cortical neurons. a The proliferative compartments of the murine telencephalon: the ventricular zone (VZ, red) and the subventricular zone (SVZ, light red). Postmitotic GABAergic neurons leave the lateral (lge) and medial (mge) ganglionic eminences and reach the striatum (Str) and through tangential migration the marginal zone (MZ) and the intermediate zone (IZ). b Part of the cortex is enlarged in which radial migration of neurons (A) through the subplate (SP) to the cortical plate (CP) and tangential migration, occurring in the ventricular, subventricular and intermediate zones (B, C), is indicated.

The early choroid plexus of the lateral ventricle is lobulated with vessels running in the mesenchymal stroma and forming capillary nets under the single-layered ependyma. The embryonic choroid plexus is converted into the fetal type during the ninth week of development as the embryonic capillary net is replaced by elongated loops of wavy capillaries that lie under regular longitudinal epithelial folds (Kraus and Jirásek 2002). 10 tensions of the arachnoid into the interior of the brain that form the vela interposita.

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