Download PDF by Nikolaos S. Voros, Christos P. Antonopoulos: Cyberphysical Systems for Epilepsy and Related Brain

By Nikolaos S. Voros, Christos P. Antonopoulos

This ebook introduces a brand new cyberphysical method that mixes medical and uncomplicated neuroscience study with complex facts research and scientific administration instruments for constructing novel purposes for the administration of epilepsy. The authors describe the algorithms and architectures had to offer ambulatory, diagnostic and long term tracking companies, via multi parametric facts assortment. Readers will see how one can in attaining in-hospital caliber criteria, addressing traditional “routine” clinic-based provider reasons, at decreased expense, more advantageous potential and elevated geographical availability. The cyberphysical procedure defined during this e-book is versatile, might be optimized for every sufferer and is tested in numerous case studies.

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Extra resources for Cyberphysical Systems for Epilepsy and Related Brain Disorders: Multi-parametric Monitoring and Analysis for Diagnosis and Optimal Disease Management

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Therefore, the connection structure of the neuronal network (rather than the density of existing neurons) seems to be of high importance to epileptogenesis [91, 92]. The fact that there is a wide diversity of seizure types, apparent causes and the variety of epileptic syndromes phenomenology [93] does not make it possible for a single pathophysiologic mechanism to underlie it all. Epileptogenesis consists of a variety of intracellular, intrinsic membrane and extracellular mechanisms with neuronal plasticity and glia offering adaptation to environmental changes [94].

Fountain NB, Kim JS, Lee SI (1998) Sleep deprivation activates epileptiform discharges independent of the activating effects of sleep. J Clin Neurophysiol 15(1):69–75 68. Lawn N, Lieblich S, Lee J, Dunne J (2014) Are seizures in the setting of sleep deprivation provoked? Epilepsy Behav 33:122–125. 008 69. Baram TZ (2007) Models for infantile spasms: an arduous journey to the Holy Grail. Ann Neurol 61(2):89–91. 21075 70. Aldenhoff JB, Gruol DL, Rivier J, Vale W, Siggins GR (1983) Corticotropin releasing factor decreases postburst hyperpolarizations and excites hippocampal neurons.

Knowledge at the mesoscopic level (brain circuits) is seriously lagging behind. The most crucial question of mechanisms underlying epileptogenesis is still unanswered, although strides are currently made in this direction by molecular genetics and neuroplasticity research. 1 Basic Neurophysiology GABA is the major inhibitory neurotransmitter in the brain. GABAA receptors coupled to chloride are involved to the hyperpolarizing of membranes which enables the inhibition of neuronal activity. The chloride mediated hyperpolarizing current counterbalances the excitatory input’s depolarizing currents and needs to be overcome for an action potential to fire.

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