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Additional info for l-independence of the trace of monodromy
Although each experiment is rather expensive, it produces enough data to generate a substantial body of knowledge. Therefore, research on genomic chromatin organization is expanding rapidly and encompassing a broader spectrum of biology. 4 Genomic Effects of Histone Modifications 25 N-terminal tail Histone fold-domain 14 9 A S R T K K Q A R 18 R A K T G P G K A L Q T K T 23 A A R 4 Acetyl group (Ac) HAT + ac ac HDAC Lysine Acetyl- Lysine Fig. 3 Histone acetylation. Acetylation of histone H3 is shown as an example of post-translational modifications of histone proteins.
Nat Rev Genet 12:7–18 Zhang Z, Pugh BF (2011) High-resolution genome-wide mapping of the primary structure of chromatin. Cell 144:175–186 Part II Transcription Factor View Chapter 3 The Basal Transcriptional Machinery Abstract The identification and characterization of TSS regions, also called core promoter regions, is a pre-requisite for the understanding how Pol II transcription is controlled. Pol II is the core of the basal transcriptional machinery, which contains a large number of general transcription factors, many of them are summarized as the TFIID complex.
The darker areas in the periphery of the nucleus represent constitutive heterochromatin, whereas the lighter areas are euchromatin. The nucleolus is a nuclear sub-structure, where genes for rRNA are transcribed. b A schematic drawing of dense nucleosome packing in heterochromatin (also referred to as closed chromatin) and loose nucleosome arrangement in euchromatin (open chromatin). 1 Eu- and Heterochromatin Between cell divisions or when they are terminally differentiated, cells are in the so-called interphase.